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The nominal p value was computed by permutation testing of the enrichment score

1 Introduction Tyrosine kinases constitute a family of proteins that, upon activation, catalyze the phosphorylation of tyrosine residues on other intracellular proteins ( EGFR-TKIs is indicated for patients with a diverse array of tumors carrying EGFR mutations, encompassing non-small cell lung cancer (NSCLC), pancreatic cancer, glioblastoma, and head and neck squamous cell carcinoma (Wang et al., 2024

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