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It is considered to be the key mechanism of ROS-induced sperm damage and leads to Loss of sperm motility Abnormal sperm morphology Reduced capacity for oocyte penetration Infertility To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD)

Various studies have indicated that disruptions in circadian rhythms contribute to impaired glycemic status in humans [4-6]

These results should encourage physicians to provide early referrals to SCD patients for transplant evaluation so that the donor search can be started in a timely matter ( Although myeloablative conditioning has achieved high rates of overall and event free survival, the conditioning is too toxic for adult patients with pre-existing organ dysfunction