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Despite being designed before the emergence of several variants, including Delta and Omicron, the antigen induces cross-reactive nAb to these and several tested sarbecoviruses in mice, rabbits, and guinea pigs [152]

10.3390/antiox12010176 22 DidonaD.HertlM

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Nevertheless, the expression of major receptors (ACE2, CD147, TMPRSS2, NRP1), facilitating the entry of SARS-CoV-2 in host cells in the nervous tissues indicates their potential role in brain invasion [21, 22]