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doi: 10.1016/s0361-9230(98)00091-4, 55

60 mM for coronary) and endothelial integrity was confirmed by 50% relaxation to acetylcholine (10 M) in arteries contracted with U46619 (concentration to achieve 7080% of maximal KCl response)

Topical evidence for skin improvement is strong at the mechanism level (collagen, elastin, GAG synthesis upregulation in fibroblasts) and moderate at the human cosmetic-trial level (Leyden 2002 conference abstract