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Functional annotation genes were functionally annotated in nine major databases, including GO, KEGG, NR, EggNOG, Swiss-Prot, Pfam, Reactome, DO, and DisGeNet using Blast2go, HMMER, KOBAS, and goatools

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While it is known that skin cells can produce estrogens locally, aromatase enzyme activity is dramatically reduced to approximately 30 times lower than in premenopausal ovarian follicular tissue [10]

In addition, we show that inhibition of ferroptosis can result in attenuation of A-related lipid peroxidation and an increase in the expression of iron storage proteins in brain cortical organoids differentiated from iPSCs of AD patients compared to their isogenic controls