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In addition, capsaicin (CAP), another gut microbiota metabolite, alleviates ventilator-induced lung injury by activating Sirtuin 3 (SIRT3) to inhibit ferroptosis and maintain mitochondrial redox homeostasis (129)

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However, the study using incremental doses of APAP demonstrated that, although Il-6 was induced and Stat-3 was activated after a moderately toxic dose and a regenerating dose of APAP, activation of Il-6/Stat-3 signaling was even higher and sustained after a severely toxic dose of APAP, in which liver regeneration was impaired