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Cannav L, Perrone S, Viola V, Marseglia L, Di Rosa G

J Agric Food Chem 53:18411856

*Statistically significant difference from before treatment

Comparing germ-free mice to conventionally grown (CONV-R) mice, it has been shown that the former had increased bone mass due to their changed immunological state, which includes lower pro-inflammatory cytokines, decreased CD4+ T cells, and fewer osteoclasts/precursors in the bone marrow (220)