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Interestingly, another study confirmed that the SIRT7 can aggravate kidney damage in I/R-induced AKI, and the knockout of SIRT7 protects mice from I/R-induced AKI through inhibiting the activation of NF-B pathway and reducing the expression of pro-inflammatory factors

Isotopic tracing with 15N-labeled glutamine revealed that 57% of ammonium is recycled via GDH-mediated reductive amination, generating 15N-labeled amino acids (excluding proline and glutathione, which are synthesized directly from glutamate) (83)