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In summary, our results reveal that various variants in LMNA , including two novel variants: LMNA (L35P) and LMNA (A539V), and two pathogenic LMNA variants LMNA (E358K) and LMNA (R453W) fish exhibit significantly weaker muscle strength compared to LMNA (WT) fish, which emphasize the impact of LMNA variants on muscle endurance in adult transgenic fish (Table 2)

Findings from early translational studies showed that the CPT I inhibitor, Etomoxir, had a cardioprotective role in the ischaemic rat heart by decreasing cellular LCAC content and promoting glycolytic substrate utilization ( Limitations in the Literature A limitation of the LCAC literature is that all research was performed using non-human models of the mammalian myocardium

doi: 10.3389/fvets.2021.769837 26 GalvisRDMadridLVRamrez-VsquezN