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Variations in genes such as IL-6, which encodes interleukin-6, a cytokine involved in inflammation and immune response, can influence the extent and duration of inflammation following an injury

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Combining the easy scale-up of the DEF-CS single-cell culture system for iPSCs, the highly efficient DE induction by the STEMdiff Definitive Endoderm kit, the robust hepatic specification guided by DMSO and HGF, and the hepatocyte maturation promoted by DEX, dihexa and OSM, this improved method may allow for robust generation of homogeneous functional hepatocytes from human stem cells and opens up new possibilities for drug discovery, hepatotoxicity studies and liver regenerative therapy

10.1371/journal.pone.0162590 45 Lovric-BencicM.SikiricP.HanzevackiJ