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For example, C-terminal amides and cyclic imides are targeted by the Cullin-RING ligases FBXO31 and CRBN, respectively 28,29

Damaged dopaminergic neurons release matrix metalloproteinase 3, -synuclein, and neuromelanin that superactivated microglia, inducing reactive microgliosis, enhancing of the neurotoxicity-related mediators, such ROS (Figure 3)