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All but the most severe of cases can be successfully managed through lifestyle changes in diet and physical activity alone, although low compliance has encouraged interest in effective therapies, including gastrointestinal surgery (efficacious and long-lasting, but limited in use because of associated risks and costs) and pharmacological interventions

Its bacteriostatic properties make it particularly advantageous for long-term storage and repeated use, minimizing the risk of contamination

Certain bacteria or yeasts can convert histidine into histamine in the body, triggering an allergic reaction

Best practice is to aliquot reconstituted peptide into single-use volumes before freezing