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Role of Mammalian DNA Methyltransferases in Development

149,155 The permeability of the BBB increases and the transport capacity of the glymphatic system diminishes during the process of age, facilitating the accumulation of A and other pathological substances in the brain

The disruption of this delicate equilibrium via oxidative stress, enzymatic inactivation, or genetic mutation induces premature senescence and hemolysis in RBCs (7, 21, 36)