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Conjugation reactions usually involve metabolite activation by a highenergy intermediate and have been classified into two general types: type I (e.g., glucuronidation and sulfonation), in which an activated conjugating agent combines with substrate to yield the conjugated product, and type II (e.g., amino acid conjugation), in which the substrate is activated and then combined with an amino acid to yield a conjugated product (Hodgson, 2004)

Clinical practice and experimental research have confirmed that the Astragalus genus and its extracts can treat DKD by regulating the Wnt/-catenin pathway

doi: 10.1038/s41387-024-00285-3 288

According to the institutional review board (IRB) no formal research ethics approval or research and development approval was required as stipulated by the UK Policy Framework for Health and Social Care Research and the Health Research Authority decision tool