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Data availability The observational data that support the findings are publicly available

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To investigate whether GCG, VGF, SCG2, SCG3, and CHGA contribute to hyperglucagonemia in individuals with diabetes and diabetic mice, we examined gene expression data from cells in patients with type 2 diabetes (GSE84133) 42 and high-fat diet (HFD)-induced obese mice (GSE203151) 43