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Data availability The authors declare that the data supporting the findings of this study are available within the paper and its Supplementary Information files

Erad interplay with ER-phagy Along with ERAD-mediated clearance of misfolded, unfolded, or incompletely assembled proteins, there is increasing recognition that, via lysosomal degradation, selective autophagy of the ER (ER-phagy) also serves to dispose of misfolded proteins or protein aggregates unrecognizable by the ERAD or too large to undergo translocation from the ER into the cytoplasm for ERAD

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Metabolically Sensitive Patients Patients with existing insulin resistance, prediabetes, or a history of severe gastrointestinal distress often struggle with GLP-1 medications