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Curcumin Curcumin comes from the root of turmeric of curcuma (an herbaceous perennial of the Zingiberaceae ), includes about 28% turmeric and is commonly consumed daily throughout Asian countries without reported toxicity [119, 120]

By inhibiting NLRP3 inflammasome activation in Schwann cells after sciatic nerve injury and suppressing microglial activation in the spinal cord, it provides rapid and long-lasting relief from mechanical and cold allodynia while supporting nerve repair and regenerationoffering a disease-modifying effect rather than simple symptom masking

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