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Dox pretreatment alone delayed the onset of ferroptosis (i.e., increased D O ) in response to erastin2 in Control cells capable of expressing p21, albeit not to the same extent as nutlin-3 treatment (Fig 2B and C)

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[16] In addition to these residues, a conserved asparagine residue (Asn450) has been suggested to stabilize the substrate through the action of a hydrogen bond at the 2-hydroxyl group of the sugar substrate