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To account for the fact that glutathione mutants had shorter roots on the control plates, ratios between the average root length on each AITC concentration and on control medium are shown in Supplementary Figure S1

During the task, young individuals showed the same negative correlation, but older individuals showed a positive relation with Glx instead, showing a possible age-related adaptation such that, in IPL, higher levels of GSH are associated with a lower inhibitory tone (lower GABA+ or higher Glx)

For example, an abnormal increase in Fe 2+ in lysosomes and endoplasmic reticulum has been observed before the death of HT1080 cells induced by erastin using a variety of novel fluorescent probes ( Figure 4 ) (Hirayama et al., 2019)

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