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This triggers neuronal membrane depolarization, increased potassium efflux, and sodium influx, disrupting Ca 2 -ATPase function and leading to high intracellular calcium levels [12, 55]

In tolerance experiments with high doses of LPS-induced sepsis, changes in histone H3K4me3, H3K27me2, and histone methyltransferase complexes (102, 151, 152) can downregulate the genes encoding inflammatory factors while upregulating the anti-inflammatory factor genes (153, 154)

For example, lycopene promotes mitochondrial biogenesis and fatty acid oxidation by activating PGC1-, thereby indirectly increasing the proportion of type IIa muscle fibers

This damage eventually leads to apoptosis and necrosis of the neurons (Nicklas et al., 1985