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170 PARP1 contains 3 zinc finger domains crucial for DNAprotein interactions, shielding Cys residues from oxidation

Cangut B, Piyadeoglu D, Antonoff MB

Transport of glutathione across the mitochondrial membrane

the present review integrates these multi-axis regulatory pathways into a unified mechanistic framework, illustrating how mitochondrial damage-associated inflammatory signaling, mechanical stress-induced oxidative injury and metabolic reprogramming-driven lipid peroxidation collectively contribute to ferroptosis in tendon pathology (Fig