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On the other hand, the safe dose level of intravenously administered sodium selenite, defined as maximum tolerated dose (MTD), was reported to be 10.2 mgm 2 in terminal cancer patients and implied the importance of kidney function in the excretion of Se from selenite since the pharmacokinetic results demonstrated a linear increase in plasma Se concentration with respect to total Se dose [440]

Gemcitabine, cisplatin, and nab-paclitaxel for the treatment of advanced biliary tract cancers: a phase 2 clinical trial