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Insufficient NAD + synthesis leads to reduced mitochondrial respiration and phagocytosis, contributing to heightened inflammatory responses

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The practical research implication is substantial: studies using ipamorelin to investigate GH/IGF-1 axis effects are not confounded by concurrent activation of the hypothalamic-pituitary-adrenal (HPA) axis a major experimental advantage over GHRP-2 and GHRP-6 in any protocol where cortisol or ACTH are outcome variables, or where HPA axis activation would represent an uncontrolled experimental variable

Reprod Biol Endocrinol 16 , 80 (2018)