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In this model, ligation acts as (i) a mechanical trauma on the dentogingival area, thereby reducing tissue integrity and allowing for intense host-plaque interaction and (ii) a plaque-formation-promoting factor, thus increasing the number of bacteria

The genotoxicity of patulin can also be attributed to the ,-unsaturated lactone that induces double-stranded breaks in DNA strands (Pfenning et al., 2016)