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2) Contact-dependent suppression, such as the inhibition of conventional T cell (Tconv) activity by the surface molecule CTLA-4 competing with CD80/CD86 on APCs, inhibiting co-stimulatory signals, and upregulating PD-L1 expression (47)

Figure 5 shows the IVT for July 5th over the Mediterranean and Central Europe, highlighting a strong southeastward transport of water vapor, with values over the Soverato Gulf reaching 600 kg m s, about half of which was transported within the 300700 hPa layer

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