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Internally produced MEVs have been suggested to mediate communication along the gut-brain axis and contribute to the pathogenesis of neurodegenerative disorders like AD and PD

A systematic bibliometric analysis revealed that research on natural products for DKD treatment has grown exponentially in recent years, with research hotspots primarily focusing on oxidative stress, inflammatory responses, gut microbiota regulation, and podocyte protection (22)

Samples were centrifuged at 13,000 rpm for 20 min at 4 C