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Researchconducted by Ye Li et al

This aligns with Kyoto Encyclopedia of Genes and Genomes enrichment linked GSH metabolism to ferroptosis and TNF signaling ( 4.4 Future therapeutic targets The Nrf2/HO-1/GPX4 axis and GSH pathways are promising therapeutic targets for SAE

doi: 10.1056/NEJMoa072375 126 PandyaNDeMott-FribergRBowersCYBarkanALJaffeCA

Although the possibility of a peroxidase-based reaction had been noted, ascorbate was proposed to be oxidized by O 2 as part of a respiratory chain, possibly linked to ascorbate oxidase (Fig