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10.1001/jamaneurol.2018.0821 JAMA Neurol

GCH1/BH4/DHFR system A recent genome-wide CRISPR activation screen has identified GTP-cyclic hydrolase 1 (GCH1), a potent antioxidant that scavenges free radicals (RTA), as the key enzyme responsible for tetrahydrobiopterin (BH4) synthesis

Despite limitations, such as the lack of in-depth analyses on how these mechanisms contribute to neurodegeneration in different neuronal populations and brain areas, the article highlights lithiums exceptional pharmacology