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In the airways it slows mucociliary clearance, injures the epithelial barrier, and depletes surfactant proteins, facilitating bacillary entry into the alveoli (Tilley et al., 2015

Moreover, mitochondrial STING expedited the mitochondrial fusion that depends on the mitofusin gene (MFN1/2), which leads to ferroptosis and peroxidation of lipids (Li et al., 2021a)