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The metabolic pathways and corresponding enzymes are organized around the TCA cycle at the center, branching out to include amino acid metabolism, purine metabolism, and the glutathione cycle, highlighting the interconnectivity and complex response to the oxidative stress induced by the absence of GR

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Before binding to specific DNA locus antioxidant response elements (AREs), Nrf2 will heterodimerize with Maf or Jun proteins in the nucleus (259, 260)

A: Cagrilintide mimics amylin, which increases fullness and helps control post-meal signals