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Recently, RA pathotypes reflective of distinct fibroblast differentiation have been associated with the course of disease progression and clinical responses to different DMARDs

Table 1 Formation of major oxidants

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In transgenic FVB/N mice overexpressing the human HER-2/neu (erbB-2) oncogene, Epithalon administration results in a significant reduction in HER-2/neu mRNA levels, with a reported 3.7-fold decrease relative to saline controls