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Hierarchical clustering of commonly engaged proteins by the fold increase in target engagement in senescent versus non-senescent conditions (referred to as senescence selectivity) identified broadly highly-reactive proteins, clusters of proteins with specificity to certain chemotypes and others (such as GPX4) that were enriched in probes related to three different SCLAs (Fig

Protein alignment and phylogenetic analysis of GSTs from various plant species The Arabidopsis GST gene information was filtered out from GFF files retrieved from the NCBI FTP site (ftp: UniProt accession numbers for all the maize GST proteins that are present in the file Gramene_Protein_Desc.txt from the GRAMENE FTP site (ftp: were retrieved

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Figure 4 Iron-dependent lipid peroxidation, which causes lipid peroxides to build up and ultimately cause cell death, is a hallmark of ferroptosis