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Among these, maternal copy loss in the 15q11-q13 chromosomal region and maternal inheritance of UBE3A gene overexpression (such as in Dup15q syndrome) are both associated with the occurrence of autism (67, 68)

Other important targets include platelets and monocytes, kidneys, the central nervous system, autonomic presynaptic nerve terminals, sensory nerve endings, endocrine organs, adipose tissue, and the eye (the effects on the eye may involve smooth muscle)