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ESRD Patients on Hemodialysis The recommended starting dose is 10 mg/kg to 20 mg/kg dry body weight as a slow 2 to 3 minute bolus injection into the venous return line after each dialysis session

J Am Chem Soc 123: 56255631, 2001

Some literature has pointed out that high concentrations of B12 have been found in patients with hepatic cancer, and this correlation has been contested and refuted