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8 Follicular regulatory helper T cells Crucial players in the antigen-specific humoral response It is believed that Tfr represents one of the regulatory T cell subsets that may originate from both thymic Tregs via thymic selection and emerging antigen TCR specificity, or from CXCR5 and BCL-6-co-expressing FoxP3+ cells arising de novo in peripheral lymphoid organs (175177)

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