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Identification of the melatonin-binding SiteMT 3 as the Quinone reductase 2*

244, 245, 246, 247 This raises the intriguing possibility that pharmacological inhibitors of DNA methyltransferases and histone deacetylases, some of which are currently approved by international regulatory agencies for use in cancer patients, may limit CDDP resistance at least in part by modulating the abundance of specific microRNAs

However, no gene/pathway has been identified as unique to high-pressure adaptation, and recent findings suggest that piezophiles (microbes that thrive in high-pressure environments) employ a common adaptation strategy to cope with multiple types of stresses, such as starvation, acid, salt, temperature, oxidation, and osmosis, which may support survival at high pressure (Allemann et al., 2024