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Data analyses were performed using Flowjo V10.5.3 (BD) 3 Results 3.1 Treatment regime of the NKTL patient receiving combination therapy To study the potential outcome of combining anti-CD38 (Daratumumab) and ICI treatments, we analysed the blood samples from a relapsed/refractory patient with NKTL who was treated sequentially with Daratumumab followed by ICI (combination therapy patient)

The ratio of reduced GSH to the disulfide form (GSH/GSSG) within the endoplasmic reticulum ranges from 1:1 to 4:1, whereas the overall cellular GSH/GSSG ratio ranges from 30:1 to 100:1 (26) (Figure 2)