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In colon cancer, CD44 + CD24 + Cdx1 + cancer stem cells demonstrated resistance to paclitaxel through a Cdx1-Bcl-2-LC3 signaling pathway, facilitating autophagy-dependent survival, while p53-positive cancer stem cells favored apoptosis instead of autophagy, emphasizing different regulatory mechanisms among subsets of cancer stem cells

The primary enzymatic system responsible for reducing MetHb is the cytochrome b5-MetHb reductase pathway, where cytochrome b5 reductase uses nicotinamide adenine dinucleotide (NADH) as a cofactor to convert MetHb back to functional hemoglobin [7,8,9]

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Tesfay et al., 2019)