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Concurrently, it facilitated the phosphorylation of Smad2/3 downstream from TGF-, enhancing transduction within the TGF- signaling pathway, which subsequently promoted increased collagen content in these cells, thereby achieving significant antiphotoaging effects on the skin

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Intranasal administration is valued as a non-invasive means of both systemic and local administration with good bioavailability, rapid onset, and targeted effects on the central nervous system [13, 14]