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Along these lines, we suggest replicating the approach of the FINGER study ( 4.5 The role of the periphery in mediating resilience There is a growing understanding that organ systems outside the CNS, that is, in the periphery, demonstrate significant dysfunction in the context of AD/ADRD (Sohrabi et al., 2022)

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Applying this model to approved and withdrawn medicines, we found that aldehyde metabolites pro- duced from N-dealkylation may explain the hepatotoxicity of several drugs: indinavir, piperacillin, verapamil, and ziprasidone

The cell viability was then measured with microplate reader (Molecular Devices, Canada) by detecting the absorbance at 490 nm