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Additionally, -tocopherol was shown to induce a cytostatic effect on the cell cycle (G0/G1 arrest) in C-6 glioma cells by suppressing extracellular signal-regulated protein kinase 1/2 and protein kinase C (PKC) upstream and retinoblastoma phosphorylation downstream, leading to the suppression of cyclin E and cyclin-dependent kinase (CDK) 2/4 and activation of p27 [99]

In osteoarthritic joints, features of the local microenvironment, such as acidic synovial fluid, accumulation of reactive oxygen species, and elevated expression of matrix metalloproteinases and proinflammatory cytokines, accelerate cartilage degeneration and synovitis (Yao et al., 2023)

Abraldes 2 , Mayur Brahmania 3 and Abdel-Aziz Shaheen 3 , (1)University of Calgary, (2)University of Alberta, AB, Canada, (3)Cumming School of Medicine, University of Calgary, Calgary, AB, Canada Background: Alcohol- (AC) and non-alcohol-related cirrhosis (NAC) epidemiology studies are limited by the accuracy of available administrative case definitions