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Oridinon (Ori), a natural terpenoid derived from the plant Isodon rubescens (Hemsl.), can increase cardiac Gln levels and inhibit the decline of ATP/ADP ratio, protecting cardiomyocytes and reducing infarct size in a rat model of myocardial injury

Analogous to its role in adipocytes, GPR81 activation in cancer cells decreases intracellular cAMP and suppresses proteinkinase A (PKA) activity, thereby modulating lipid remodeling (55,56)

Therefore, a strategy that concurrently modulates metabolic pathways and disrupts intercellular communication represents a potential synthetic lethal approach, providing a novel direction for the systematic targeting of tumors and the improvement of therapeutic efficacy [372]