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Dopamine system involvement adds another regulatory dimension

In the process of physiological ageing, both systemic and tissue-specific systems show functional downfalls, which, when projected to the brain, translate into weakening defence and metabolic strain resulting from age-dependent declines of the cardio-vascular system and overall decreases in metabolism

The tBid promotes the activation of mitochondrial outer membrane permeabilization (MOMP) effector proteins BAX and BAK, which further trigger the recruitment of other caspases to perform apoptosis [148]

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