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Beyond the uPA system, TF itself has emerged as a potent and specific therapeutic target, and this is because of it being the primary initiator of the extrinsic coagulation cascade, as well as being aberrantly expressed on a variety of cancer cells and on tumor-associated endothelium, where it contributes to multiple hallmarks of cancer, including sustained proliferation, evasion of cell death, angiogenesis, and activation of invasion and metastasis

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