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In animal or ex vivo experimental models for mechanistic investigation of peptidemetal interactions, copper bioavailability, and metal-mediated tissue signalling processes

During rapid weight loss, the body may undergo metabolic adaptationsometimes called "adaptive thermogenesis"where energy expenditure decreases beyond what would be expected from reduced body mass alone

Most minor reactions settle on their own, although a lump after injection in the stomach or another injection site may take time to improve

In the presence of renal or liver dysfunction, particularly in pregnancy, 2 grams or more taken daily intravenously has been associated with deaths