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Therefore, to enhance mitochondrial complex I activity, NAD + levels were boosted in fly models of PD with NAM, leading to reduced oxidative stress, including lower ROS levels and DNA damage, as well as improved climbing ability 281

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The American Institute of Medicine, Food and Nutrition Board, and the European Scientific Committee on Food, both decided not to set an upper B12 intake limit, because toxicity from overdosing on B12 poses no risk

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