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Genes with a Bonferroni-corrected P value of less than 0.05 were considered to be differentially expressed

The clinical utility of conventional copper chelators is limited by dose-dependent toxicities, primarily stemming from systemic copper deficiency and off-target chelation of essential metals, such as zinc and iron

As damage from smoking or even pollution accumulates to the respiratory tract and the lungs, oxygen and carbon dioxide (CO2) exchange suffers, making it difficult to breathe

In particular, we previously showed that CD38 is the main NAD + -hydrolyzing enzyme in mammalian tissues, and its upregulation largely accounts for age-dependent decline in NAD + 11,17,18,19