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ZBP1-MLKL necroptotic signaling potentiates radiation-induced antitumor immunity via intratumoral STING pathway activation

For instance, the M83 mouse expressing mutant human syn demonstrates that abnormal syn accumulation is sufficient to drive neurodegenerative phenotypes including neuronal hyperactivity and vascular patterning defects, even in the absence of overt systemic inflammation [164, 165]