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Quality control in aminoacyl-tRNA synthesis: its role in translational fidelity

In the presence of DNA damage one of the earliest key factors of the DNA repair Histone H2ax is phosphorylated to H2ax thereby allowing the assembly of DNA repair-related proteins to DNA (Kobayashi, 2004

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Another proposed mechanism involves the binding of homocysteine to the collagenous matrix of bone, which may modify collagen properties and reduce bone strength (reviewed in 113)