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In fact, B cells are increased in TDLNs and they produce pathogenic IgG that interacts with heat shock protein family A member 4 (HSPA4), activating the NF-B pathway that mediates the activation of the CXCR4/SDF1 axis (188)

So, like, for example, in 2016, they did a study

Notably, targeting the structurally accessible P1P2 regions within pathogenic -syn oligomers and fibrils offers a promising therapeutic strategy for selectively inhibiting aggregation, thereby supporting the development of more effective disease-modifying treatments (Brcenas et al., 2026)

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